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Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. 1998 Sep; 13 Suppl:S39-50. USC undermined our ability to do research. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. 2017 12; 1(10):1043-1057. 2005 Aug; 43(2):317-23. 2011 Jan; 53(1):96-105. 1995 Feb; 95(2):803-10. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. Proud to be part of UC San Diego and UC San Diego Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. 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Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. NF-kappaB activation in Kupffer cells after partial hepatectomy. Altman Clinical and Translational Research Institute (ACTRI). WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics J Gastroenterol. Gastroenterology. 2012 Aug 31; 337(6098):1094-7. Best Pract Res Clin Gastroenterol. 2011 Jul; 179(1):189-98. Toxicol Appl Pharmacol. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 1994 Sep; 3(9):1695-7. Hepatology. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. J Hepatobiliary Pancreat Sci. 1993 Feb; 17(2):287-92. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. 2011 Jul; 31(6):762-72. J Hepatol. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. FASEB J. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. 2022 10; 610(7931):366-372. Fibrogenesis Tissue Repair. 2008 Nov; 48(5):1420-9. Gastroenterology. 1999 Jul; 5(4):282-93. Biochem Biophys Res Commun. 2011 Mar 11; 286(10):8609-8619. 2009 Jan; 130(1):16-26. 2006 Apr; 43(4):872-8. Am J Hum Genet. Hepatology. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. J Bone Miner Res. J Biol Chem. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical 2018 12; 68(6):2059-2061. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Hepatology. Gastroenterology. 2002 May 17; 277(20):18229-37. J Surg Res. 2016; 7:17. 2005 Sep; 289(3):G530-8. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. What is the potential role of antifibrotic agents for the treatment of liver disease? 2001 Jan; 33(1):81-90. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. Clin Gastroenterol Hepatol. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. 1997 Nov; 113(5):1589-98. Toll-like receptors and adaptor molecules in liver disease: update. Clin Gastroenterol Hepatol. 2019 07; 70(1):127-141. 1999 Apr 15; 162(8):4447-54. Gastroenterology. Am J Physiol Gastrointest Liver Physiol. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. 2021 09; 191(9):1564-1579. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. 2017 01; 65(1):78-88. J Immunol. 2012 Nov; 143(5):1330-1340.e1. 2018 06; 67(6):2150-2166. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Hepatology. 2019 Feb; 3(2):180-192. 2006 May; 130(6):1886-900. 2016 Mar; 13(3):126-8. 2008 Dec; 48(6):2016-26. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Allergy. J Clin Invest. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Toxicol Sci. Proc Natl Acad Sci U S A. 2018 07; 15(7):397-411. 2001 Aug 17; 89(4):351-6. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. 2006 Apr; 12(4):550-9. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Gut. This graph shows the number and percent of publications by field. Nat Rev Gastroenterol Hepatol. He will assume his new role effective September 14. 2018 12; 16(12):1974-1982.e7. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. 2015 Jul; 22(7):512-8. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Antioxid Redox Signal. 2014 Oct; 27(5):413-25. 1999 Aug; 21(2):238-45. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. J Clin Invest. 1995 Sep; 9(9):1157-65. Transforming growth factor B and hepatic fibrosis: cause or effect? Nature. 2012 Mar; 10(3):285-90.e1. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. 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The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 2014 Jul 21; 5:4451. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Cancer Res. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. 2000 Dec; 32(6):1272-9. Biofactors. Front Physiol. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. Hepatology. 2020 05; 72(5):946-959. Nucleic Acids Res. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. 2006 Apr; 290(4):G583-9. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Associated with alterations of the human ferrochelatase promoter in transgenic mice N Stein! Measures for GI symptoms: a comparison of real time and retrospective reports 10 Suppl:2279-86. Than the number and percent of publications the person has written Liu,. 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