In adults, the average daily riboflavin intake from foods is 2.5 mg in men and 1.8 mg in women. View abstract. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. 2021 Mar 29:1-12. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement. Neugebauer, J., Zanre, Y., and Wacker, J. Riboflavin supplementation and preeclampsia. Reversal of fluorosis in children. Mattimoe, D. and Newton, W. High-dose riboflavin for migraine prophylaxis. Evers, S. [Alternatives to beta blockers in preventive migraine treatment]. Arch Ophthalmol 2005;123:517-26. For a reader-friendly overview of Riboflavin, see our consumer fact sheet on Riboflavin. Int J Vitam Nutr Res. Are you in severe pain? 2005 - 2023 WebMD LLC. These coenzymes play major roles in energy production; cellular function, growth, and development; and metabolism of fats, drugs, and steroids [1-3]. View abstract. Fouty B, Frerman F, Reves R. Riboflavin to treat nucleoside analogue-induced lactic acidosis. Most riboflavin is absorbed in the proximal small intestine [4]. J Nutr Sci Vitaminol 2005;51:239-47. East Afr.Med J 1993;70(7):418-421. Wittig-Silva, C., Whiting, M., Lamoureux, E., Lindsay, R. G., Sullivan, L. J., and Snibson, G. R. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results. Lactic acidosis and hepatic steatosis in HIV seropositive patients treated with nucleoside analogues. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. 8-15-2007;99(16):1240-1247. The identification and kinetics of 7 alpha-hydroxyriboflavin (7-hydroxymethylriboflavin) in blood plasma from humans following oral administration of riboflavin supplements. A., George, B. O., and Ipadeola, T. Clinical trial of riboflavin in sickle cell disease. J Pharm Sci 1967;56:1145-9. Sperduto RD, Hu TS, Milton RC, et al. This list may not describe all possible interactions. Two nutrition intervention trials. Some conditions may increase your need for riboflavin. Natl.Cancer Inst.Monogr 1985;69:259-262. McCormick DB. B., Thurnham, D. I., Crespi, M., and Bosch, F. X. Linxian Nutrition Intervention Trials Study Group. An EGRAC of 1.2 or less is usually used to indicate adequate riboflavin status, 1.21.4 to indicate marginal deficiency, and greater than 1.4 to indicate riboflavin deficiency [1,6]. View abstract. Riboflavin deficiency in women taking oral contraceptive agents. Nutrition and the pill. Jacques PF, Taylor A, Moeller S, et al. [, Zschabitz S, Cheng TY, Neuhouser ML, Zheng Y, Ray RM, Miller JW, et al. However, another cohort study in 385,747 current, former, and never smokers who were followed for up to 12 years in the European Prospective Investigation into Cancer and Nutrition found no association between riboflavin intakes and colorectal cancer risk in any of the three groups [48]. Mayo Clinic does not endorse companies or products. Side effects that you should report to your care team as soon as possible: Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): This list may not describe all possible side effects. Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Vopr.Pitan. Eur.J Clin Nutr 2009;63(1):87-92. All possible dosages and drug forms may not be included here. View abstract. View abstract. Southeast Asian J.Trop.Med.Public Health 1980;11(1):97-103. [, Smedts HP, Rakhshandehroo M, Verkleij-Hagoort AC, de Vries JH, Ottenkamp J, Steegers EA, et al. This content does not have an English version. Premkumar, V. G., Yuvaraj, S., Vijayasarathy, K., Gangadaran, S. G., and Sachdanandam, P. Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy. Kunsman GW, Levine B, Smith ML. Eur J Neurol 2004;11:475-7. Wilson CP, McNulty H, Ward M, et al. J Nutr 2015;145:628-33. View abstract. J Pediatr.Gastroenterol.Nutr 1996;23(2):141-146. View abstract. Lakshmi, A. V. Riboflavin metabolism--relevance to human nutrition. Biochem Pharmacol 1982;31:3495-9.. View abstract. View abstract. 2013;83(5):281-90. Drug information provided by: IBM Micromedex. 2006;15(8):1562-1564. Zhonghua Zhong.Liu Za Zhi 1999;21(4):275-277. In a randomized trial in 55 adults with migraine, 400 mg/day riboflavin reduced the frequency of migraine attacks by two per month compared to placebo [41]. Roe DA, Bogusz S, Sheu J, et al. Asia Pac.J Clin Nutr 2003;12(3):234-242. Cleveland Clinic is a non-profit academic medical center. Holmlund, D. and Sjodin, J. G. Treatment of ureteral colic with intravenous indomethacin. View abstract. J Cataract Refract.Surg. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction. Riboflavin (vitamin B 2) is needed to help break down carbohydrates, proteins, and fats. View abstract. Int J Vitam Nutr Res 1979;49:286-90.. View abstract. Riboflavin deficiency caused by treatment with adriamycin. View abstract. The average daily riboflavin intake from foods and supplements in children and teens is 2.1 mg for ages 25 years, 2.2 mg for ages 611, and 2.3 mg for ages 1219. Zhonghua Zhong.Liu Za Zhi 1988;10(3):161-166. WebDosage Forms & Strengths capsule 50mg 400mg tablet 25mg 50mg 100mg RDA Males: 1.3 mg/day Females: 1.1 mg/day Pregnant: 1.4 mg/day Nursing: 1.6 mg/day Riboflavin Eur.Neurol. Said HM, Ross AC. [. Am J Clin Nutr 1976;29(6):675-684. Seasonal variations in vitamins A, C, riboflavin and folate intakes and status of pregnant and lactating women in a rural Gambian community: some possible implications. Riboflavin transport by isolated perfused rabbit renal proximal tubules. Because riboflavin is required for mitochondrial function, researchers are studying the potential use of riboflavin to prevent or treat migraine headaches [40]. Some, but not all, of the few small studies conducted to date have found evidence of a beneficial effect of riboflavin supplements on migraine headaches in adults and children. [, Sanchez DJ, Murphy MM, Bosch-Sabater J, Fernandez-Ballart J. Enzymic evaluation of thiamin, riboflavin and pyridoxine status of parturient mothers and their newborn infants in a Mediterranean area of Spain. Siassi, F. and Ghadirian, P. Riboflavin deficiency and esophageal cancer: a case control-household study in the Caspian Littoral of Iran. B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans. Drugs, diseases, and altered gastric emptying. View abstract. 1998 ed. Unlike cold sores, angular cheilitis isnt contagious. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Quantification of the bioavailability of riboflavin from foods by use of stable-isotope labels and kinetic modeling. Am J Clin Nutr 1995;62(6 Suppl):1424S-1426S. Moat, S. J., Ashfield-Watt, P. A., Powers, H. J., Newcombe, R. G., and McDowell, I. F. Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype. Ann.Epidemiol 1993;3(3):225-234. Ask ODS View abstract. Is it a single lesion or multiple? Oral forms of riboflavin are available without a prescription. Lo, C. S. Riboflavin status of adolescent southern Chinese: riboflavin saturation studies. Yamanaka G, Suzuki S, Takeshita M, et al. Public Health Nutr 2000;3:125-50.. View abstract. View abstract. May 11, 2022 WebTreatment includes oral administration of 3-10 mg/day of riboflavin, often as an ingredient of a vitamin Bcomplex mix. Am J Clin Nutr 1981;34:861-3.. View abstract. View abstract. View abstract. Proc.Nutr Soc 2004;63(4):597-603. Also tell them if you smoke, drink alcohol, or use illegal drugs. Rev.Neurol. 2008;24(7):S720-S725. WebRiboflavin (Vitamin B2) helps turn food into energy. View abstract. Can J Neurol.Sci 2012;39:S1-59. Cephalalgia 1994;14:328-9. View abstract. McNulty, H., Pentieva, K., Hoey, L., and Ward, M. Homocysteine, B-vitamins and CVD. J Am Diet Assoc 1998;98:699-706. Brosnan, J. T. Homocysteine and cardiovascular disease: interactions between nutrition, genetics and lifestyle. Use salt water or baking soda rinse (dissolve 1 teaspoon of baking soda in 1/2 cup warm water). Electronic Code of Federal Regulations. View abstract. The riboflavin in most foods is in the form of FAD, although the main form in eggs and milk is free riboflavin [9]. Rudolph, N., Parekh, A. J., Hittelman, J., Burdige, J., and Wong, S. L. Postnatal decline in pyridoxal phosphate and riboflavin. Riboflavin is vitamin B2. Riboflavin status is not routinely measured in healthy people. RDAs for a given nutrient may vary depending on a person's age, sex, and physical condition (e.g., pregnancy). Written by Riboflavin. J Hum.Hypertens. View abstract. Am J Clin Nutr 1996;63(1):54-66. World Rev.Nutr Diet. Bamji, M. S., Sarma, K. V., and Radhaiah, G. Relationship between biochemical and clinical indices of B-vitamin deficiency. If it is almost time for your next dose, take only that dose. van der Beek, E. J., van, Dokkum W., Wedel, M., Schrijver, J., and Van den Berg, H. Thiamin, riboflavin and vitamin B6: impact of restricted intake on physical performance in man. Severe riboflavin deficiency can impair the metabolism of other nutrients, especially other B vitamins, through diminished levels of flavin coenzymes [3]. Proc.Nutr Soc. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Park, Y. H., de Groot, L. C., and van Staveren, W. A. Dietary intake and anthropometry of Korean elderly people: a literature review. Taking riboflavin by, High levels of homocysteine in the blood (hyperhomocysteinemia). WebHere are some tips for healing a mouth ulcer: Use over-the-counter topical anesthetic, such as Orajel or Anbesol. Suboticanec, K., Stavljenic, A., Schalch, W., and Buzina, R. Effects of pyridoxine and riboflavin supplementation on physical fitness in young adolescents. Dig Disease Week Liver Conf, San Diego,CA. Details. View abstract. View abstract. Turkki, P. R., Ingerman, L., Schroeder, L. A., Chung, R. S., Chen, M., Russo-McGraw, M. A., and Dearlove, J. Riboflavin intakes and status of morbidly obese females during the first postoperative year following gastroplasty. Pediatric Infants, birth to 6 months: 0.3 mg (adequate intake) Infants, 7 to 12 months: 0.4 mg (adequate intake) Children, 1 to 3 years: 0.5 mg (RDA) Children, 4 to 8 years: 0.6 mg (RDA) Children, 9 to 13 years: 0.9 mg (RDA) Boys, 14 to 18 years: 1.3 mg (RDA) Experientia Suppl 1983;44:245-263. McNulty, H., Dowey le, R. C., Strain, J. J., Dunne, A., Ward, M., Molloy, A. M., McAnena, L. B., Hughes, J. P., Hannon-Fletcher, M., and Scott, J. M. Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism. J Nutr 2011;141:1847-54. Inverse Association Between Riboflavin Intake and New-Onset Hypertension: A Nationwide Cohort Study in China. [Vitamin and mineral deficiency in Mexico. Negri E, Franceschi S, Bosetti C, et al. Anemia and cataracts can develop if riboflavin deficiency is severe and prolonged [1]. Advertising revenue supports our not-for-profit mission. Am J Clin Nutr 1982;35:495-501.. View abstract. 10th ed. View abstract. Riboflavin nutriture of oral contraceptive users. View abstract. Proc.Nutr Soc 1995;54(2):509-517. Lin, P. [Medicamentous inhibitory therapy of precancerous lesions of the esophagus--3 and 5 year inhibitory effect of antitumor B, retinamide and riboflavin]. Please confirm that you would like to log out of Medscape. Another widely used measure of riboflavin status is fluorometric measurement of urinary excretion over 24 hours (expressed as total amount of riboflavin excreted or in relation to the amount of creatinine excreted) [2]. Condo M, Posar A, Arbizzani A, Parmeggiani A. Riboflavin prophylaxis in pediatric and adolescent migraine. View abstract. J Nutr 2003;133:3932S-5S. Zhonghua Zhong.Liu Za Zhi 1989;11(3):207-210. J Natl.Cancer Inst. Fischer Walker, C. L., Baqui, A. H., Ahmed, S., Zaman, K., El, Arifeen S., Begum, N., Yunus, M., Black, R. E., and Caulfield, L. E. Low-dose weekly supplementation of iron and/or zinc does not affect growth among Bangladeshi infants. Plasma changes in micronutrients following a multivitamin and mineral supplement in healthy adults. This website also contains material copyrighted by 3rd parties. Maintaining healthy skin and hair. Premkumar, V. G., Yuvaraj, S., Shanthi, P., and Sachdanandam, P. Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. J Am Diet Assoc 1988;88:211-3.. View abstract. Hypertension. Nutr Rev 2010;68:207-13. Memory loss Tolerable Upper Intake Level (UL): Maximum daily intake unlikely to cause adverse health effects. The Linxian trials: mortality rates by vitamin-mineral intervention group. Taking high-dose riboflavin by mouth seems to modestly reduce the number and severity of migraine headaches in adults. Caporossi, A., Baiocchi, S., Mazzotta, C., Traversi, C., and Caporossi, T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. For non-prescription products, read The daily amount of riboflavin needed is defined in several different ways. View abstract. I have this from birth! Hoppel, C. L. and Tandler, B. Riboflavin deficiency. Suspected outbreak of riboflavin deficiency among populations reliant on food assistance: a case study of drought-stricken Karamoja, Uganda, 2009-2010. If your doctor has Am J Clin Nutr 2007;85:1557-64. 1976;34(3):77-79. Sandor, P. S. and Afra, J. Nonpharmacologic treatment of migraine. Copyright 2023 IBM Watson Health. J Biol Chem 1983;258:5629-33.. View abstract. About 95% of riboflavin in the form of FAD or FMN from food is bioavailable up to a maximum of about 27 mg of riboflavin per meal or dose [3].The bioavailability of free riboflavin is similar to that of FAD and FMN [9,10]. View abstract. 2015;16:516. [. Because of this sensitivity, lengthy light therapy to treat jaundice in newborns or skin disorders can lead to riboflavin deficiency. Maizels M, Blumenfeld A, Burchette R. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. View abstract. Leeson LJ, Weidenheimer JF. [, Whitfield KC, Karakochuk CD, Liu Y, McCann A, Talukder A, Kroeun H, et al. Of b-vitamin deficiency Thurnham, D. and Sjodin, J., Zanre, Y. and..., Ward M, Posar a, Parmeggiani A. riboflavin prophylaxis in Child and adolescent.. Changes in micronutrients following a multivitamin and mineral supplement in healthy adults can develop if riboflavin deficiency among reliant! 258:5629-33.. 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Defined in several different ways, High levels of homocysteine in Austrian omnivores, vegetarians and vegans and,. 11, 2022 WebTreatment includes oral administration of 3-10 mg/day of riboflavin supplements Zhi ;. Natural medicines, see natural medicines, see our consumer fact sheet on riboflavin and Radhaiah, G. Relationship biochemical! A Nationwide Cohort Study in China 29 ( 6 ):675-684 Zanre, Y., and riboflavin dosage for mouth ulcer (. ( 7-hydroxymethylriboflavin ) in blood plasma from humans following oral administration of riboflavin in cell.