Pickup & Same Day Delivery available on most store items. Foods Am J Clin Nutr 1995;62:604-10. View abstract. View abstract. J Matern Fetal Neonatal Med 2020:1-6. Trumbo, P. R. and Ellwood, K. C. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. This can increase their risk for developing deficiencies and experiencing disorders as they age. Gouado, I., Schweigert, F. J., Ejoh, R. A., Tchouanguep, M. F., and Camp, J. V. Systemic levels of carotenoids from mangoes and papaya consumed in three forms (juice, fresh and dry slice). 2004;3(6):310-316. J Am Coll Nutr 2001;20(3):232-238. Luckily, doctors now have the ability to measure macular pigment levels of lutein in someones eyes in order to determine if that person is at an increased risk for disease. Chen F, Hu J, Liu P, Li J, Wei Z, Liu P. Carotenoid intake and risk of non-Hodgkin lymphoma: a systematic review and dose-response meta-analysis of observational studies. That said, possible lutein and zeaxanthin side effects can include harmless yellowingof the skin calledcarotenemia and an upset stomach/vomiting if you take too much. Dietary lutein and cognitive function in adults: A meta-analysis of randomized controlled trials. Invest Ophthalmol.Vis.Sci. Int.J.Vitam.Nutr.Res. Riccioni, G., Speranza, L., Pesce, M., Cusenza, S., D'Orazio, N., and Glade, M. J. View abstract. J.Nutr. Rosenthal, J. M., Kim, J., de, Monasterio F., Thompson, D. J., Bone, R. A., Landrum, J. T., de Moura, F. F., Khachik, F., Chen, H., Schleicher, R. L., Ferris, F. L., III, and Chew, E. Y. Dose-ranging study of lutein supplementation in persons aged 60 years or older. View abstract. View abstract. Early childhood lutein and zeaxanthin intake is positively associated with early childhood receptive vocabulary and mid-childhood executive function but no other cognitive or behavioral outcomes in project viva. Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults. Eczema is a skin condition that affects around 1530% of children and 210% of adults ().Scientists have found the cause of eczema may be mostly genetic. Relationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer. View abstract. View abstract. View abstract. Role of lutein supplementation in the management of age-related macular degeneration: meta-analysis of randomized controlled trials. 2003;94(1):57-63. 2014;52(4):198-205. Researchers at Harvard University have found that supplementing with lutein daily can lower the risk for macular degeneration. Br J Nutr 2004;92(1):113-118. Pratt S. Dietary prevention of age-related macular degeneration. Ros, M. M., Bueno-de-Mesquita, H. B., Kampman, E., Aben, K. K., Buchner, F. L., Jansen, E. H., van Gils, C. H., Egevad, L., Overvad, K., Tjonneland, A., Roswall, N., Boutron-Ruault, M. C., Kvaskoff, M., Perquier, F., Kaaks, R., Chang-Claude, J., Weikert, S., Boeing, H., Trichopoulou, A., Lagiou, P., Dilis, V., Palli, D., Pala, V., Sacerdote, C., Tumino, R., Panico, S., Peeters, P. H., Gram, I. T., Skeie, G., Huerta, J. M., Barricarte, A., Quiros, J. R., Sanchez, M. J., Buckland, G., Larranaga, N., Ehrnstrom, R., Wallstrom, P., Ljungberg, B., Hallmans, G., Key, T. J., Allen, N. E., Khaw, K. T., Wareham, N., Brennan, P., Riboli, E., and Kiemeney, L. A. 2008;87(6):1837-1843. View abstract. View abstract. Liew SH, Gilbert CE Spector TD Mellerio J Van Kuijk FJ Beatty S Fitzke F Marshall J Hammond CJ. Am.J.Clin.Nutr. Vorgerd M, Grehl T, Jager M, et al. View abstract. J Nutr 1997;127:1636S-45S. View abstract. It seems that people with this disorder might not absorb some carotenoids from food very well and often show low blood levels of lutein. View abstract. Am.J.Clin.Nutr. View abstract. View abstract. WebLutein, zeaxanthin, lycopene, and astaxanthin belong to a group of nutrients called carotenoids. View abstract. View abstract. Wu J, Cho E, Willett WC, Sastry SM, Schaumberg DA. Rubin, L. P., Chan, G. M., Barrett-Reis, B. M., Fulton, A. View abstract. Keep in mind that as with other antioxidants, people seem to differ in terms of how capable their bodies are of absorbing lutein. J Clin Med 2019;8(1):77. Superior bioavailability of a novel lutein and zeaxanthin formulation in healthy human subjects. J Aging Res 2019;2019:3709402. Invest Ophthalmol.Vis.Sci. 2011;24 Suppl 1:147-150. Ophthalmology 2002;109:2272-8.. View abstract. 1999;19(6):491-495. Optometry 2004;75:216-30. Eur.J Clin.Nutr. View abstract. View abstract. Nutrients 2022;14(4):872. Olmedilla, B., Granado, F., Southon, S., Wright, A. J., Blanco, I., Gil-Martinez, E., Berg, H., Corridan, B., Roussel, A. M., Chopra, M., and Thurnham, D. I. Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries. View abstract. Read Next: Top 7 Ways Carrot & Carrot Juice Benefit Your Body. Lutein is an orange-colored nutrient. Central retinal thickness is positively correlated with macular pigment optical density. Lyle BJ, Mares-Perlman JA, Klein BE, et al. Johnson EJ, Hammond BR, Yeum KJ, et al. 2013 Jan;30(1):25-32. Mares-Perlman JA, Brady WE, Klein BE, et al. Stedman's Medical Dictionary. Lyle BJ, Mares-Perlman JA, Klein BE, et al. Curr Dev Nutr 2021;5(10):nzab123. Valero, M. P., Fletcher, A. E., De Stavola, B. L., Vioque, J., and Alepuz, V. C. Vitamin C is associated with reduced risk of cataract in a Mediterranean population. 2014 Dec 16;56(1):252-8. Review. Lutein supplements have been used safely by adults in doses up to 15 to 20 milligrams daily for as long as two years without any serious side effects. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Long-term supplementation with alpha-tocopherol and beta-carotene and age-related cataract. Reboul E, Thap S, Perrot E, et al. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. I. Arch.Ophthalmol. A. Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. Mares-Perlman, J. View abstract. View abstract. Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men. Ophthalmology 2012;119(11):2282-2289. Ophthalmology 2003;110(1):51-60. Other benefits of lutein for eye health include: When it comes to eye health, every person is different in terms of how much lutein is most beneficial. Neuroepidemiology. View abstract. Hammond BR Jr, Johnson EJ, Russell RM, et al. Takeda, S., Masuda, Y., Usuda, M., Marushima, R., Ueji, T., Hasegawa, M., and Maruyama, C. Effects of mayonnaise on postprandial serum lutein/zeaxanthin and beta-carotene concentrations in humans. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Cancer Epidemiol.Biomarkers Prev. Int J Food Sci Nutr 2016;67(7):744-53. Note that the numbers in parentheses (1, 2, etc.) Am J Epidemiol 1999;149:801-9. Bartlett, H. E. and Eperjesi, F. A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. Slattery ML, Potter JD, Coates A, et al. Mol.Nutr.Food Res. Arch.Biochem.Biophys. Age-Related Eye Disease Study 2 Research Group. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. JAMA Ophthalmol 2022. Molldrem, K. L., Li, J., Simon, P. W., and Tanumihardjo, S. A. Lutein and beta-carotene from lutein-containing yellow carrots are bioavailable in humans. WebThe best antihistamine for eczema is the one that relieves your symptoms. 2012;32(6):418-424. Berendschot, T. T., Broekmans, W. M., Klopping-Ketelaars, I. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Wright, A. J., Hughes, D. A., Bailey, A. L., and Southon, S. Beta-carotene and lycopene, but not lutein, supplementation changes the plasma fatty acid profile of healthy male non-smokers. Hozawa, A., Jacobs, D. R., Jr., Steffes, M. W., Gross, M. D., Steffen, L. M., and Lee, D. H. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. View abstract. Positive effects of lutein and zeaxanthin supplementation and topical application of these carotenoids have been shown to be beneficial for the skin. Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. Bates, C. J., Chen, S. J., Macdonald, A., and Holden, R. Quantitation of vitamin E and a carotenoid pigment in cataractous human lenses, and the effect of a dietary supplement. Estimates show that more than 25 million people worldwide are affected by age-related macular degeneration or cataracts, especially people aged 55 and older living in industrialized Western nations. View abstract. View abstract. 2002;56(7):615-621. Robman, L., Vu, H., Hodge, A., Tikellis, G., Dimitrov, P., McCarty, C., and Guymer, R. Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration. Ophthalmol Sci 2021;1(3):100039. Within the eyes, one of the most important functions of the lens is to collect and focus light on the retina. View abstract. 2015 Aug 25;314(8):791-801. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. View abstract. Gartner, C., Stahl, W., and Sies, H. Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human. View abstract. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. View abstract. Am J Clin Nutr 1999;70(4):490-494. View abstract. Paetau, I., Rao, D., Wiley, E. R., Brown, E. D., and Clevidence, B. Murray, I. J., Makridaki, M., van der Veen, R. L., Carden, D., Parry, N. R., and Berendschot, T. T. Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. Some animal studies show evidence that lutein offers significant protection against light-induced skin damage, such as signs of aging and potentially skin cancer. Nutrients. This information may not fit your specific health circumstances. View abstract. Am J Clin Nutr 2000;71:575-82. In fact, eye vitamins with lutein are some of the bestvitamins for macular degeneration. View abstract. View abstract. 2011;94(5):1211-1218. Med.Sci.Sports Exerc. Gastroenterology 1989;97:1033-42. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Plasma antioxidant vitamins and carotenoids and age-related cataract. The effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported mild cognitive complaints: A randomized, double-blind, placebo-controlled study. View abstract. 2012;17(3):3202-3242. View abstract. The answer will tell you how much lutein youre getting. Cancer Causes Control 2003;14(7):645-655. Similarly, other studies show that higher dietary intakes ofzeaxanthin and lutein along with other natural antioxidants, includingvitamin C,beta-caroteneandvitamin E, are associated with a significantly decreased risk of cataract formation. View abstract. Background: Low intakes of dietary antioxidants may contribute to increases in asthma and allergy. View abstract. Ma, L., Yan, S. F., Huang, Y. M., Lu, X. R., Qian, F., Pang, H. L., Xu, X. R., Zou, Z. Y., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., Dou, H. L., and Lin, X. M. Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration. 2010;21(6):544-549. Holtan, S. G., O'Connor, H. M., Fredericksen, Z. S., Liebow, M., Thompson, C. A., Macon, W. R., Micallef, I. N., Wang, A. H., Slager, S. L., Habermann, T. M., Call, T. G., and Cerhan, J. R. Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Hammond, B. R., Jr., Curran-Celentano, J., Judd, S., Fuld, K., Krinsky, N. I., Wooten, B. R., and Snodderly, D. M. Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. Johnson, E. J. JAMA 2013;309(19):2005-2015. 2004;80(1):131-136. Lutein vitamin is considered a natural treatment for macular degeneration symptoms (AMD), which is considered the most common cause of blindness among older adults. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. 2002;75(3):540-549. Am J Clin Nutr 2012;96(2):356-373. Heinrich, U., Gartner, C., Wiebusch, M., Eichler, O., Sies, H., Tronnier, H., and Stahl, W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J.Nutr. Johnson, E. J., McDonald, K., Caldarella, S. M., Chung, H. Y., Troen, A. M., and Snodderly, D. M. Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. According to the American Macular Degeneration Association, the following foods are the best sources of luteinfor increasing your intake naturally (not to mention for getting other antioxidants, vitamins and minerals too): Lutein andzeaxanthin foods are important maculardegeneration vitamins. What are the precautions when taking this product? Some evidence shows that people who obtain more lutein from their diets experience lower rates of breast, colon, cervical and lung cancers. Eur.J.Nutr. View abstract. are clickable links to these studies. WebLutein is a type of vitamin that is called carotenoid. Cangemi, F. E. TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD. WebOverview. Hankinson SE, Stampfer MJ, Seddon JM, et al. A. Our team aims to be not only thorough with its research, but also objective and unbiased. 2000;9(3):257-263. Front Nutr 2022;9:924997. Asian Pac J Cancer Prev. View abstract. Arch.Ophthalmol. View abstract. 2001;42(1):235-240. The average person who eats the standard American diet is likely running low in this carotenoid, in addition to other important antioxidants. 2006;47(12):5227-5233. View abstract. Chew, E. Y., Clemons, T., SanGiovanni, J. P., Danis, R., Domalpally, A., McBee, W., Sperduto, R., and Ferris, F. L. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Epidemiology. Nutrients 2016;8(7). Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli, Brussels sprouts, eggs, oranges, and papaya. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. Kim MK, Ahn SH, Lee-Kim. View abstract. Antioxidant status and neovascular age-related macular degeneration. View abstract. Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. Snodderly DM. Edwards CG, Walk AM, Thompson SV, et al. Exp Eye Res 1997;65:57-62. J.Nutr. Information from this source is evidence-based and objective, and without commercial influence. View abstract. Arterioscler.Thromb.Vasc.Biol 2004;24(2):313-319. Arch Ophthalmol 1993;111:761-72. Invest Ophthalmol Vis Sci 1997;38:1795-801.. View abstract. Am J Clin Nutr 2000;71:950-5. Shinojima A, Sawa M, Sekiryu T, et al. View abstract. Thyagarajan, B., Meyer, A., Smith, L. J., Beckett, W. S., Williams, O. D., Gross, M. D., and Jacobs, D. R., Jr. Serum carotenoid concentrations predict lung function evolution in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study. A. View abstract. Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Juturu V, Bowman JP, Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin Cosmet Investig Dermatol 2016;9:325-332. View abstract. Associations of serum carotenoids with risk of cardiovascular mortality among individuals with type 2 diabetes: Results from NHANES. View abstract. WebThe B Vitamins are essential in improving skin conditions such as eczema. The lutein and zeaxanthin used was an ingredient known as Lutemax 2020 from supplier OmniActive Health Technologies. Junghans, A., Sies, H., and Stahl, W. Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. A case-control study. Moeller, S. M., Voland, R., Tinker, L., Blodi, B. Am J Clin Nutr 2004;79 1045-52. View abstract. View abstract. Juturu V, Bowman JP, Deshpande J. View abstract. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. JAMA Ophthalmol. Adv Nutr 2021. Richer, S. ARMD--pilot (case series) environmental intervention data. View abstract. Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. Mares-Perlman JA, Brady WE, Klein R, et al. Invest Ophthalmol Vis Sci 2015;56(13):8069-74. Shao, A. and Hathcock, J. N. Risk assessment for the carotenoids lutein and lycopene. Eye Disease Case-Control Study Group. Graefes Arch.Clin.Exp.Ophthalmol. Clin Cosmet Investig Dermatol 2016;9:325-332. View abstract. Herron, K. L., McGrane, M. M., Waters, D., Lofgren, I. E., Clark, R. M., Ordovas, J. M., and Fernandez, M. L. The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs. The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population. You already know that filling up on plenty of fruits and veggies is good for you, and heres just another example of why that is. Am J Clin Nutr 2003;78(5):985-992. View abstract. However, most studies show that benefits are greatest when someone consumes 10 milligrams of lutein per day or more (along with about two milligrams of zeaxanthin perday). 2010;9:22. JAMA 2005;294:3101-7. Duncan, J. L., Aleman, T. S., Gardner, L. M., De Castro, E., Marks, D. A., Emmons, J. M., Bieber, M. L., Steinberg, J. D., Bennett, J., Stone, E. M., MacDonald, I. M., Cideciyan, A. V., Maguire, M. G., and Jacobson, S. G. Macular pigment and lutein supplementation in choroideremia. Djuric, Z., Uhley, V. E., Naegeli, L., Lababidi, S., Macha, S., and Heilbrun, L. K. Plasma carotenoids, tocopherols, and antioxidant capacity in a 12-week intervention study to reduce fat and/or energy intakes. Kotagiri SR, Morde A, Rai D, et al. View abstract. View abstract. 2008;27(2):218-227. By performing a macular pigment optical density test (MPOD), doctors can better give specialized dietary recommendations for protective nutrients based on individual responses, genetic predisposition and lifestyle factors. Traditionally lutein is characterized by its blue light filtering and anti-oxidant properties. View abstract. 2020;12(10):2966. 2014;42(1):25-38. J Nutr 1999;129(12):2162-2169. J Epidemiol Community Health 1998;52:468-72. Eur.J.Clin.Nutr. View abstract. Zinc is an important mineral that plays a key role in skin health (17). Berendschot, T. T., Goldbohm, R. A., Klopping, W. A., van de, Kraats J., van Norel, J., and van Norren, D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Rapp, L. M., Maple, S. S., and Choi, J. H. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Xu J, Song C, Song X, Zhang X, Li X. Carotenoids and risk of fracture: a meta-analysis of observational studies. J Nutr 2006;136(5):1161-1165. Olmedilla, B., Granado, F., Blanco, I., and Vaquero, M. Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. 2007;61(10):1180-1188. Nutr.J. Lutein and its relative zeaxanthin are pigments called carotenoids. Ito, Y., Wakai, K., Suzuki, K., Ozasa, K., Watanabe, Y., Seki, N., Ando, M., Nishino, Y., Kondo, T., Ohno, Y., and Tamakoshi, A. Lutein and zeaxanthin intake during pregnancy and visual function in offspring at 11-12 years of age. Dietary lutein plus zeaxanthin and choline intake is interactively associated with cognitive flexibility in middle-adulthood in adults with overweight and obesity. Abnet, C. C., Qiao, Y. L., Dawsey, S. M., Buckman, D. W., Yang, C. S., Blot, W. J., Dong, Z. W., Taylor, P. R., and Mark, S. D. Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. Prog Retin Eye Res. View abstract. 2007;61(9):1121-1127. Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression. Zhou Y, Wang T, Meng Q, Zhai S. Association of carotenoids with risk of gastric cancer: a meta-analysis. Am.J.Epidemiol. Neutrogena Norwegian Formula Dry Hand Cream. View abstract. 2007;125(9):1225-1232. Am.J.Clin.Nutr. Objective: We investigated the association of maternal total intakes (foods + supplements) of 10 antioxidant nutrients during pregnancy with wheezing and eczema in 2-y-old children. Kiokias, S. and Gordon, M. H. Dietary supplementation with a natural carotenoid mixture decreases oxidative stress. View abstract. 60 Count (Pack of 1) 4.5 4.5 out of 5 With dry eye disease, also known as dry eye syndrome, your eyes dont make enough lubrication to coat your eyes. This can cause red, itchy, burning, eyes, temporary blurriness, and a feeling as if theres sand in your eye. According to a 2016 study, lutein may help reduce these symptoms. How much lutein do you need? This daily supplementation decreased the risk of macular degeneration from intermediate to advanced stages by 25%. Goltz, S. R., Campbell, W. W., Chitchumroonchokchai, C., Failla, M. L., and Ferruzzi, M. G. Meal triacylglycerol profile modulates postprandial absorption of carotenoids in humans. Arch.Ophthalmol. BMJ 10-13-2007;335(7623):755. Nutrients. View abstract. View abstract. 2012;70(4):234-240. A., Gao, Y. T., Goodman, M. T., Hallmans, G., Helzlsouer, K. J., Hoffman-Bolton, J., Hulten, K., Sesso, H. D., Sowell, A. L., Tamimi, R. M., Toniolo, P., Wilkens, L. R., Winkvist, A., Zeleniuch-Jacquotte, A., Zheng, W., and Hankinson, S. E. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. Pool-Zobel, B. L., Bub, A., Muller, H., Wollowski, I., and Rechkemmer, G. Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods. Optom Vis Sci 1997;74:499-504. J Nutr.Biochem. Adackapara, C. A., Sunness, J. S., Dibernardo, C. W., Melia, B. M., and Dagnelie, G. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. Nutr.J. Supplementation with carotenoids, omega-3 fatty acids, and vitamin E has a positive effect on the symptoms and progression of Alzheimer's disease. Ghasemi F, Navab F, Rouhani MH, Amini P, Shokri-Mashhadi N. The effect of lutein and Zeaxanthine on dyslipidemia: A meta-analysis study. J Lab Clin Med 1999;134(6):592-598. Atherosclerosis Risk in Communities. 2013;73(2):236-45. Curr.Eye Res. Am.J.Ophthalmol. View abstract. Ge XX, Xing MY, Yu LF, et al. Lyle, B. J., Mares-Perlman, J. BMC Pregnancy Childbirth 2022;22(1):427. View abstract. Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). If you suspect you might benefit from high doses of lutein, its best to speak with your doctor to rule out any potential contraindications. 2010;97(1):36-40. Eur.J.Clin.Nutr. Oncotarget 2017;8(2):2391-9. Lutein and zeaxanthin supplementation in preterm very low-birth-weight neonates in neonatal intensive care units: a multicenter randomized controlled trial. Dani, C., Lori, I., Favelli, F., Frosini, S., Messner, H., Wanker, P., De, Marini S., Oretti, C., Boldrini, A., Massimiliano, C., Bragetti, P., and Germini, C. Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study. Rock, C. L., Flatt, S. W., Wright, F. A., Faerber, S., Newman, V., Kealey, S., and Pierce, J. P. Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence. View abstract. Am.J.Clin.Nutr. Invest Ophthalmol.Vis.Sci. Steinmetz KA, Potter JD. Giving preterm infants lutein and zeaxanthin by mouth doesn't prevent retinopathy of prematurity. View abstract. Bahrami, H., Melia, M., and Dagnelie, G. Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289]. View abstract. Nutr.Rev. View abstract. View abstract. View abstract. Arch.Biochem.Biophys. Ma, L., Dou, H. L., Huang, Y. M., Lu, X. R., Xu, X. R., Qian, F., Zou, Z. Y., Pang, H. L., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., and Lin, X. M. Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. View abstract. An eye disorder in premature infants that can lead to blindness (retinopathy of prematurity). 2012;56(1):126-146. As another example, one group of people who can usually afford to take more is those with cystic fibrosis. J.Matern.Fetal Neonatal Med. Zhao, X., Aldini, G., Johnson, E. J., Rasmussen, H., Kraemer, K., Woolf, H., Musaeus, N., Krinsky, N. I., Russell, R. M., and Yeum, K. J. VandenLangenberg GM, Mares-Perlman JA, Klein R, et al. USCs observational studies show that people with the highest levels of lutein in the blood experience less plaque buildup in the arteries, while the opposite is also true: The fewer lutein-rich plant foods someone eats, the more clogged their arteries seem to become. Dorgan, J. F., Boakye, N. A., Fears, T. R., Schleicher, R. L., Helsel, W., Anderson, C., Robinson, J., Guin, J. D., Lessin, S., Ratnasinghe, L. D., and Tangrea, J. Cancer Epidemiol.Biomarkers Prev. Kang T, Liu Y, Chen X, et al. Schalch, W., Cohn, W., Barker, F. M., Kopcke, W., Mellerio, J., Bird, A. C., Robson, A. G., Fitzke, F. F., and van Kuijk, F. J. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study. 8-15-2012;92(10):2043-2049. Diet and lifestyle correlates of lutein in the blood and diet. View abstract. 2000;71(3):239-245. Chasan-Taber L, Willett WC, Seddon JM, et al. J Am Optom.Assoc 1999;70(1):24-36. Garca-Layana A, Recalde S, Alamn AS, Robredo PF. Piermarocchi, S., Saviano, S., Parisi, V., Tedeschi, M., Panozzo, G., Scarpa, G., Boschi, G., and Lo, Giudice G. Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study. A., and Guymer, R. H. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. Manzoni P, Guardione R, Bonetti P, et al. Xiong K, Zhao Y, Hu S, Ma A, Ma Y. Dose-response relationship between oral lutein intake and plasma lutein concentration: A randomized controlled trial. 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