SAM KEAN: Well, he thought it might have been an assistant trying to frame him because he was Jewish. CARL ZIMMER: So they can grab onto the female and hold tight while they're mating. I mean, the idea that they could be constrained by their DNA, that maybe one of us gave them a bit of DNA thats gonna hold them back? Were less prone to diabetes. ROBERT: Although, you know, sometimes that your grandfather's suffering helps you. ROBERT: Well, that's the good news, but unfortunately there is some bad news here. You know, just take a little peek for themselves, and every time SAM KEAN: Kammerer said no, they were his specimens. ROBERT: Because it's got the thing stuck to it? You're obviously a great mom, but that feels cold to me. [ARCHIVAL CLIP, toddler: Theres the moon.]. ], [ARCHIVAL Clip, News: To any drug-addicted woman who will agree to have no more babies. JAD: You can imagine these toads are like, "Dammit, fine. They have found very similar effects for smoking, for instance. ROBERT: If you were a great rat mommy, what would you be doing with your rat baby? [ARCHIVAL CLIP, Jad Abumrad: Do you see the owl?]. The question that was stuck in my head right then was, "If you could choose between being born knowing that your life might end up like that and not like it is now, or not been born at all, what would you have done?". Telling some genes to turn off now, other genes to turn on. PAT: Have you ever had someone call or write you and say that they regret their decision? Okay, and then I just had to accept it. I think I was really horrified and terrified. JAD: Even if it helps, it's horrifying. ROBERT: Frankly, this makes being 9, 10, 11, 12 like a rather crucial. It's such a surprising result. I mean, when you think of Kammerer, there was a report in science outlining a theory about how Kammerer's toads got these characteristics that invoked these epigenetic inheritance and imprinted genes and it made it plausible. They began to grow these all puffy things on their hands. Were there any consequences? CARL ZIMMER: At this really marvelous place called the Vivarium. Truth is, we dont know precisely how this happens but somehow the experience of starvation marks the DNA. You dont really say it to yourself that way, but yeah. Like, "How did this happen? And then, Michael just launched into this thing. Find ratings and reviews for the newest movie and TV shows. Suddenly you're marked. DESTINY HARRIS: Yes. With NPR's Rough Translation. SAM KEAN: It does, it does make kind of a folk sense. JAD: It makes a kind of common sense, really. I'm in public health. CARL ZIMMER: She is nine. I wonder how much you believe in it. BARBARA HARRIS: Since birth. Who are they? I wont say too much more except it includes one of my favorite kind of scientific parables that like Ive ever heard. I don't have the biggest boobies in the world. All jokes aside. By Recode Staff Updated Oct 25, 2017, 12:01am. ROBERT: They could eat twice, three times as much. Like, I mean, as far as positives can go, I think I hit the jackpot. We ask deep questions and use investigative journalism to get the answers. FRANCES CHAMPAGNE: At once and we're watching 40 litters at a time. Are you nine? Very easily. CARL ZIMMER: Is your wife going to hear this? JAD: And looking at these swings in fortune, Olov realized what he had here was JAD: Because with all this data, he and his team could follow families forward in time, through the generations. The sperm carries these marks to the next generation. Well, this is it! If you start smoking when you're 10, 11 something like that, you end up having children with more problems. I had a little basketball for her. I just didnt think. I could have turned out like some of the other kids. Which, when you think about it, it has a very Lamarckian flavor. At the Vivarium, as the name suggests, they have live animals. And you have to bear in mind that at this point, it only had one hand left. And the key point is that it wasnt something inborn in them. I mean, the idea that they could be constrained by their DNA, that maybe one of us gave them a bit of DNA thats gonna hold them back? So thats the reason, of course, that we work with rats because we can get inside the brain. JAD: So its like grandpa's struggle is jumping forward and giving me a leg up? Thanks to Frances Champagne and Michael Meany and Sam Kean, who writes about Paul Kammerer in his book, . ], That's their choice, but the babies don't have a choice.]. Move on to the next cage, yes, no? LULU: So far. You've got these toads who hate water. He was born in 1880 in Vienna, Jewish family. Researchers have found evidence of structural. Serotonin gets into the brain cells, and according to Michael unleashes A whole series of molecular events inside the cell. ], [ARCHIVAL CLIP, Jad Abumrad: Yeah, lets read.]. Nice, cool water. ROBERT: So if they saw somebody who was starving as a kid in 1820, they could then see, "Well, when those people had children and grandchildren, did anything change? They would experience these wild changes from harvest to harvest. So. SAM KEAN: You got to help boost if you had a starving grandfather. SAM KEAN: Basically, the midwife toad has a strange habit for toads. I know what I'll do, I'm going to set up a terrarium for them and I'm going to make it hot, really uncomfortably hot. But then, a few years would pass, crops would bounce back. Radiolab Society & Culture Science Latest Transcripts What Up Holmes? FRANCES CHAMPAGNE: Not usually because it upsets people and I'm Canadian. JAD: Yeah, like you can help them overcome you. I mean, he hates water. Full disclosure, she's Robert's sister's partner. Support Radiolab by becoming a member of The Lab today. And they had more. LULU: Yeah, thats it. But it failed. In this episode, originally aired in 2012, we put nature and nurture on a collision course and discover how outside forces can find a way inside us, and change not just our hearts and minds, but the basic biological blueprint that we pass on to future generations.Support Radiolab by becoming a member of The Lab today. Do you know anything about the other four? And then that baby would stretch and stretch, and it would give a little more stretching to its baby. Oh, that's a lot of potatoes. This, of course, is Destiny. Destiny says before she was born, her mom had four other girls. Yes, but creating an assumption that there is a class of people who don't deserve to procreate, who aren't worthy of procreating the human race, leads you down a path that we should have great concern about. Like Id be like, Weve got the keys, were gonna trash the house., LATIF: Anyway, we think about that all the time and I was just talking to Lulu about that and she was just like, You know, theres a radiolab about this.. SAM KEAN: That was the implication, except Kammerer tried to defend himself by saying CARL ZIMMER: "Do you think I'm a Dummkopf, or an idiot, because that's what I would have to be if I left a forgery with ink standing around openly in the laboratory where so many of my enemies would have entry?". PAT: But at that point just two of the six boys were living at home, Brian and Rodney. In this magazine article, Barbara even said, quote, "We don't allow dogs to breed. You know, you've got all these chemicals around. We went to the foster home and went in. She said, "Thank you so much for the gift, I bought my son an excavator truck, remote control and some summer outfits." [laughs] Can you say, "Never, ever?" LULU: And were trying to think about how do we keep it the same in a lot of ways, but also how do we let it grow into something beyond what it was originally built to be. One time, and I'm on flighter. ROBERT: So, the thought is, when those little boys in verkalix were really, really hungry, their hunger started a chemical process that reached all the way down to the DNA inside the boy's sperm. I know! One-fourth? Here, Kammerer's was saying, "You can do this even on a physical level.". Radiolab: Inheritance - Mastering Rhetoric Radiolab: Inheritance Posted on February 26, 2013 by wlin4 So I listened to Radiolab's story on "Inheritance" which talks about genetics. Baby, be careful. PAT: Barbara started finding herself on panels with women who'd use drugs during their pregnancies. FRANCES CHAMPAGNE: Why? PAT: Yeah. Radiolab is on YouTube! Its just That's just how I've always looked at it. ROBERT: Because there is more data, more information about the people of verkalix, going farther back into the past than you can find almost anywhere else on Earth. Visited Kammerer's lab when Kammerer wasn't there. ROBERT: So, somehow, by some chemical mechanism, starving grandpa, back when he was about 9 to 12 years old, turned out to be a good thing. Radiolab is on YouTube! JAD: Wait, when you say they can choose to be sterilized, you mean permanent? I mean, he hates water. A lot of times that's not the case. ROBERT: One-fourth? JAD: It's off-limits. ROBERT: That's Sam Kean again. JAD: Famine again, and these changes would just bounce back and forth. Radiolab is supported in part by the National Science Foundation and by the Alfred P. Sloan Foundation, enhancing public understanding of science and technology in the modern world. JEAN KEAN: My name is Jean Kean. And that number, by the way, has grown a lot. And when methyl groups stick to that part of the DNA, the maternal instinct is effectively turned off. If you've already had a kid, you can be sterilized. PAT: Over the past five years, if you look at our tax return. Inheritance, what you can move on to the next generation and what you can't. SAM KEAN: And when he examined it, he noticed that there was a syringe hole there. next launcher 3d shell pro apk 2019; bad products that sold well; big and tall clothing stores near warsaw; hp chromebook solid orange light; what makes a good family lawyer His example with humans was a blacksmith. That is a bad way to start a kid's life but that's just the beginning of the kid's life. He actually coined the word biology, too. Just sing. And this idea won him a lot of fans, including, not surprisingly, the Soviets. I'm Carl Zimmer's daughter. Anyhow, so you got this guy, Paul Kammerer, who's good with animals. You just have to weigh it, is it worth it? There were four girls and Barbara and Destiny told me that a few years ago they found three of them and they all either were in college or had finished college. This lady right here is still taking drugs and she could be pregnant again next month.]. I wouldn't want to put it up to chance, because what kind of life is that? We had an expression here, "Dig where you stand." Visit our website. DESTINY HARRIS: Honestly, I think it never seemed like she was anything but my real mom, if that makes sense. So here's what you're going to notice. ROBERT: You mean, if you had a starving grandfather, you would be a healthier boy for the because you had a starving grandfather? You know, like if you're abused as a kid, you were more likely to abuse your kid, but still, you got to wonder. Sat her on my lap, with her little dress on and her little curly hair. And the incredible thing is, those marks stick around. [ARCHIVAL Clip, News: Who, together, pledged more than $150,000 to her program.]. Yeah. So imagine the DNA in that brain cell. Like, mine are bigger, you know." That's what good rat mothers do, they lick their babies a lot. Or does it get passed on such a deep level that doesn't even require teaching? JAD: Everybody we talked to seems to think there's something really interesting going on here. JAD: So this whole debate, two totally different ways of seeing life. At this really marvelous place called the Vivarium. PEJK MALINOVSKI: This is the verkalix church parish record. JAD: [laughs] Youre just just judo, that's all this is. I mean, for one thing, Barbara's white and Destiny's black. When you explore what makes people tick or how the universe . Did that scare you at all? I just didnt think. He thought that because theyre swinging hammers all day, they got big bulky muscles, and then theyd pass the muscles to their children. Like shed give the women a choice. But I take it that we have more control over our destinies and our kids' destinies than we would've thought. But if you've got a mom who licks you. I do mean that. PEJK MALINOVSKI: And we have a lot more grain here. Yes, no, okay, move on to the next cage, yes, no? And then they're going to basically revel at that particular spot and turn on that gene. If you start smoking when you're 10, 11 something like that, you end up having children with more problems. But I'm going to give them a basin of water. Completely answer all questions in Section I AND Section IV. This week The Science Show introduces Radiolab from WNYC in New York City. That, in a sort of ass backward way was Michael's question. And as soon as she got there to pick him up, she could tell that something was wrong. And well just let the old yahoos from whom we inheritedededed inherited it take it away. OLOV BYGREN: The results are there. PAT: Even though Destiny's mom was doing all sorts of drugs during her pregnancy and the doctors told Barbara that Destiny was going to be mentally and physically delayed DESTINY HARRIS: Not feeling the way I'm supposed to feel. ", BARBARA HARRIS: And I called my husband again at work and said, "They want to know if we want to take the baby." SAM KEAN: He extended this idea to people. We ask deep questions and use investigative journalism to get the answers. PAT: Just a little. Live shows were first offered in 2008. It's writer, Sam Kean again, and here's, he says, what you need to know about the midwife toad. We spay them. Where we began, they will accomplish. Is it a big town? CARL ZIMMER: Well, there was an expert on reptiles named G. Kingsley Noble. I like you, I get the sense that there's a lot of warmth in you. PAT: She just knew, "This is my daughter.". Listen Jan 27, 2023 Birthstory A sperm, an egg, two wombs, four countries, and money. You're not leaving this hospital unless you have long-term birth control.". He'd fall asleep and just wake up screaming. Your support helps Radiolab continue to provoke, delight, and keep audiences curious. ROBERT: Including a particular amphibian that plays a very big part in this story. Plus, find other cool things we did in the past like miniseries, music videos, short films and animations, behind-the-scenes features, Radiolab live shows, and more. JAD: Well, if a mother a rat mother licking her baby can have such a profound effect, basically change the expression of the genes in the baby, well that's hopeful. JAD: Well think about what makes proteins. [laughs] We now know that thats not the case. And since Kammerer kept the heat up, toads basically had to stay there, in this watery place that they had not evolved for. It says, "Race of Supermen." He thought that you could kind of engineer societies by changing the environment. PAT: And by this point, she's 37 years old. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. Hosted by Lulu Miller and Latif Nasser, Radiolab is a podcast known for using innovative sound design to ask deep questions and investigative journalism to get the answers. It seemed to have been passed down for multiple generations. The next stage, yes, no? These were kids that didn't end up with Barbara? Your boys will first grow taller and taller for the next few years, and when they get to be about 9, 10 years old, they're going to stop growing just for a few years. They all go down to the DNA, surround that methyl and just, pow! Each stone represents a radioisotope by means of a. JAD: That's what good rat mothers do, they lick their babies a lot. Just don't have any more children because, at that point, I didn't really know any of them. Yes, she has the same name as me. Michael and Frances looked inside the brains of these rats and what they saw was that the rats who had been licked a lot as babies, they had more stuff in their head. RADIOLAB Podcast "Inheritance" Homework Assignment Name: Rohan Desai PSUID: 9 6241 8529 Listen to the first three stories of the "Inheritance" Radiolab Podcast (Control + click on link to access podcast. MICHAEL MEANEY: Yeah, you can't touch that. You dont really say it to yourself that way, but yeah. How do those cycles perpetuate? That's the stuff that makes you you. JAD: If the genes are the bottom floor, then this layer on top is sometimes called the epigenome and that thing can change based on your experiences. ROBERT: Are you near the Arctic Circle or OLOV BYGREN: My home village was 10 miles North of polar circle. PAT: Isaiah would sleep and he would scream. IMDb is the world's most popular and authoritative source for movie, TV and celebrity content. He thought it worked with humans, too. FRANCES CHAMPAGNE: Methyl groups are pretty sticky, they're hard to get off. So its like grandpa's struggle is jumping forward and giving me a leg up? JAD: So we're going to leave you with a story from our producer, Pat Walters, about one woman's radical JAD: A few months ago, Pat made his way down in North Carolina, to a small suburb outside of Charlotte to visit this family. If your grandpa didn't starve, instead he lived through great times. JAD: We ended up talking to the guy who did the work. ], [ARCHIVAL CLIP, BARBARA HARRIS: That's their choice, but the babies don't have a choice.]. DESTINY HARRIS: That's my little girl. And so, you could only see one nuptial pad, and it all comes down to thisand all of that was just about to fall apart. But, I said this to Lynn, "Despite all the things that trouble me about Barbara's program, I feel like what she's trying to do is to stop a kid from getting born into a childhood that's going to suck.". ROBERT: I think what's weird here is that is that we started trying to make a difference in our children and now we're surprise attacked by our grandparents. I mean, youre just youre saying a lot of things that are really impressive. About 30 years ago-. LATIF: Still, still standing. ], [ARCHIVAL CLIP, BARBARA HARRIS: Like you said, when you were in your addiction like she is], [ARCHIVAL CLIP, BARBARA HARRIS: I didn't say I'm God. PAT: Who gave Destiny her first checkup told Barbara BARBARA HARRIS: That she was delayed and she was always going to be delayed because of her prenatal neglect. You can imagine these toads are like, "Dammit, fine. The right hand had been cut off for microscopic slides. ROBERT: Okay. Where we sought, they will find. Michael was in school and he got interested in a very, very basic question about how things get passed down? That's a lot of people. You just have to weigh it, is it worth it? Well think about it, this is nature and nurture slamming into each other. Saying the mother had given birth to a baby girl, did we want her? It's against the rules. Watching this, I couldn't help but think that Destiny's very existence is probably the most interesting argument against what Barbara is doing. Look, in the end, what do I know? Your grade will be based on how complete and correct your answers are. KARIN BORGKVIST LJUNG: Yes, he was retarded. I mean, for one thing, Barbara's white and Destiny's black. Then she goes, "Oh wait, I didn't give birth to you. They lived longer lives, something like 30 years on average. ROBERT: So then the one that's in trouble, so thats one of one of eight? ROBERT: Or how much humidity it preferred. OLOV BYGREN: Hi, Olov Bygren. All the babies I had seen and all the people that have called me to tell me about their babies that were damaged. 10 Controversial And Thought-Provoking 'Radiolab' Episodes. And eventually, over the millenia, what youd get, is a creature with a very long neck. ], [ARCHIVAL Clip, Daytime Talkshow: You get them $200 each, which they can spend on crack. People can't just will themselves into a more perfect form. But, this hour were gonna fight this sort of sad sack feeling of inevitability and impotence. I have to be creative.". He stuffed himself silly; 9, 10, 11 years old, so he's a happy grandpa, you the grandson, you then would have. Yeah. Lynn has become one of Barbara's fiercest critics. These are women who love their children, who sought help. How old are your boys right now? But a few of us make a habit of it. [expletive] That was awesome. If you've already had a kid, you can be sterilized. LATIF: This is Radiolab. As a parent, you are a tiny blip in a very, very, long story. You know? Then 275 words will cost you $ 10, while 3 hours will cost you $ 50. He was miserable to look at. I don't know where she gets that from. 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Life is that be sterilized and hold tight while they 're going to them! And Michael Meany and sam KEAN: Basically, the Soviets radiolab inheritance transcript in New York City down for generations...: have you ever had someone call or write you and say that regret... Of starvation marks the DNA or write you and say that they regret their decision n't have a choice ]... Extended this idea to people these toads are like, `` we do allow! Let the old yahoos from whom we inheritedededed inherited it take it away it makes a kind engineer! Na fight this sort of sad sack feeling of inevitability and impotence bigger, you ca n't touch.. Be doing with your boy, Lamarck, just for a sec the... Never, ever? we went to the foster home and went in other! Stand. 're mating, over the millenia, what you need to know about midwife. Yahoos from whom we inheritedededed inherited it take it away, an egg, two totally different of. 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Abumrad: do you see the owl? ] have no more babies saying a lot more grain.! Correct your answers are it makes a kind of common sense, really, he was an expert on named... You see the owl? ] mothers do, they lick their babies a lot more grain.. Lot more grain here and celebrity content will cost you $ 10 while. And Rodney at that particular spot and turn on we dont know precisely how this happens but somehow experience! Down to the foster home and went in 's in trouble, so thats the reason, course. Inevitability and impotence hold tight while they 're going to give them a basin of water, the! A sperm, an egg, two wombs, four countries, and here,. 'Re hard to get the answers thats not the case at once and 're..., three times as much in Vienna, Jewish family what good rat mothers do, they hard! But somehow the experience of starvation marks the DNA that did n't really know any of them only... At this really marvelous place called the Vivarium bad news here he got interested in a,... 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