He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. I did find another one in New Hampshire but I know like everyone else that all we be negative just like all tests done so far. The same thing possibly is happening to my 9 month old Boxador. I wish I would have read these comments first. I will be speaking to vet to switch to something else. The vet insisted it was not from the Simparica Trio. The initial trial had seizure results but supposedly only in dogs with seizure history. Hey Sara I was wondering how you contacted Simparica because after taking her to animal emergency room then the vet next day. How is your dog now? She is healing and has no new rashes or sores. Simparica Trio is intended for dogs and puppies weighing more than 2.8 pounds and older than 8 weeks of age. What Are Potential Simparica Trio Side Effects in Dogs? I also reported to drug manufacturer and they are willing to reimburse me for the costs incurred. I will never give another dose to him! Head down, facing the wall, tremors, lethargic, and she can't seem to see well. Im praying over him too . She looked it up and said they were a ton of recalls and she admitted to me that that is what possibly killed him because it was on the recalls and theyd had mini dogs come in for the same issue. I'm besides myself. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. She has been itching uncontrollably since I gave her the simparica. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. The other has had diarrhea every since 6 hours after the pill. Contrary to the statement in that same above article "The results are fatal for fleas and ticks but safe for mammals such as your dog." His first was a week after taking his simparica. It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. I can tell something is off with her I just couldnt figure it out. Hello! She has been on our property for four year and has survived everything. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. It kills heartworm larvae by causing paralysis that leads to the death of the parasite. Wonder why PetSmart offers this if there are so many concerns reported. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. Will NEVER give this to my dog again. It is now day 37 since her last Simparica and I will not ever give her another one. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. I will be discontinuing the medication. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. I would not recommend giving Simparica to your pets!!!!! Itching has decreased immensely. He had ONE dose that evening and completely lost his appetite within a couple days. In addition to the tremors, have you noticed any . I began researching this today as the same thing seems to be happening to my Havanese mix since starting this several months ago. Hoping that these side effects dont get worse and subside soon . Mine is due for another dose next week and I don't know what to do. I gave my dog simparica trio. They got him to eat a little the next morning and sent him home. My dog is 9 yrs old . There is NO other explanation for this rapid decline and the only change has been THIS drug. I give my dogs Simparica at the beginning of each month. First time for this adverse reaction. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. (145 Reviews) $15.50 - $31.09. She had right sided weakness, with right sided neglect( the inability to process stimuli with impaired spatial recognition ). Please anyone let me know if there is a class action law suit or where we can start one? It has a good rating also 4.7 out of 5. But then the first time I increased from 6mg to 12mg (again on advice of the vet) as his weight increased, the tremors got noticably worse and he started stumbling for no reason. The Trio product by Simparica is a three-in-one medication to control and prevent flea, tick, and heartworm. Seizures continue and its Monday. I feel so sad for you Camelia. I definitely will not poison her with this garbage anymore. oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. While veterinarians often prescribe medications for off-label uses, your veterinarian will determine whether Simparica is right for your pet. Omg, this is beyond awful and makes me so worried. The prescription-only chewable tablet is given once a month to dogs and puppies eight weeks and older. I will never use this product again!!!!! The vet did a nasal lavage under anesthesia and got a lot of mucus. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. I just wanted them gone and for him to feel better. In addition to ease of use, it has been tested in many field trials and proven to work effectively against fleas, ticks, and worms in dogs. Vet said they dont think it has anything to do with the Simparica. He protected our livestock from coyotes for many years and I took good care of him. I have had German Shepherds for 40 yrs. She didn't make it to the next day and died overnight. Benefits: Each tablet provides a full month of protection against fleas and ticks. Glad i held off on the free sample i was given! If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. Trifexis is much safer and I really don't care about the ticks - I can pull those off. As I read all the comments I am so alarmed. I called the vet and of course they do not think it's the pill but I know it was. Now tremors started. And yeah he ate today 4 chicken breast and appeared to want it even better. After about a week, she started to improve. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. It can also cause seizures and tremors, but those side effects are incredibly rare. So sad as he was once a happy healthy dog with no prior health issues. Also I read on Dr Mercola site that heartworms is in the dogs blood not the digestive track and garlic won't work. Blood work + urine sample. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). Within 24 hours, he would not leave my bedroom, slept all day, no appetite. I've tried Gatorade and Ginger ale but he only drank a little. Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . ALL oral tick meds are in the same class of drugs, so cannot give anything with that in it. We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. The cardiologist found no heart condition that would cause this. I've had to syringe water in his mouth. Needless, to say I will not be giving them the simparica trio again. He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. Daily Paws is part of the Meredith National Digital Network. The vet recognized immediately that she was in severe neurogical distress. We tried stopping the simparica. Vet says garlic doesn't work and obviously it didn't because he shaved a little of dogs fur and put it on a paper towels and it was full of fleas.The vet gives me Simpirica-ok fleas are dropping off him like crazy. We took him to the animal er and they checked his vitals and he was fine. Please advise! Called Vet tonight and got a first appointment for tomorrow morning . What are the side effects of Simparica Trio for Dogs? However, doing nothing is better than giving her the Simparica. Im petrified after reading the comments here. She has been the healthiest, happiest dog. If she had just taken it they could give her Charcoal. It could be a coincidence but seems too coincidental. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . How common are Simparica side effects? It should be given to your dog once a month and comes in a liver flavor and dogs will likely enjoy the taste. He is fully housebroken and just had a running stool accident in the house. Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. This morning was the first morning he left water in his bowl. The next morning, she had uncontrollable tremors and could not walk without falling down. I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. Unfortunately, I didn't realize the tremors were possibly caused by the drug. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. What do I do? My Juno has been eating and playing but she is very tired more tired than usual. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. It's only available with a prescription from your veterinarian, so you . She has episodes where she seems very anxious and is hiding under car/tables/beds. I hate that I did this to her and I hate that the Vet does not seem to care. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. She hasn't had any of the diarrhea or eating issues, but has had one of her eyes that gets red and the inner eyelid partially covers her pupil. No appetite, not like Charlie. Gave my 28lb German Spitz her monthly prescibed dose of Simparica. Instead it has become a world of greed. Both my dogs have had runny eyes and were eating grass all summer. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. Any believers out there please say a prayer for our pup as I will for the people on this thread. If undiagnosed he would have died. My vet recommended the tablet to save on monthly costs for flea and tick treatment. Previously B was on Heartgard and Advantix worked well I guess we switch back. In very rare instances, mild side effects and irritations can occur for a short period of time. I should have kept with my gut feeling about any of these oral meds. I sadly started my beautiful dog on Simparica Trio on May 1, 2021. Hi how is your pup now? I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. We wont be using this medicine ever again! Use a collar or topical if you need to. It was the first time she had taken Simparica. These are the side effects that were observed: Most common is vomitting Weakness and lethargy Soft stools Loss of appetite Im going to another vet and discontinuing simparica. Then suddenly dog has diarrhea and it lasted for several days. Is your dog still having tremors? It hurts to see this and infuriating to know these stories are out here and we did not do the research before giving our little guys this poison. She's pacing and wants to eat grass. Is due for another tablet but I have been holding off. I hope for all of you that your pets (loved ones) have improved, I know the feeling of total helplessness to help them and all you can do is wait and hope. I thought it was them not liking the food and made a change. Customer: Took a dose of simparica trio.second rose in second month.dog is having tremors JA: I'll do all I can to help. The only thing the vet told me was that his ATL liver enzyme levels were just slightly high (170) and it wasn't a concern and we could just do another blood test at his next check-up. I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. This medication should be banned and the company held responsible. This is so awful. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. The issues started within 24 hours of the dose and continue. How is your dog doing? I called the maker of Simparica and filed an FDA case for my dog and told them all of the symptoms she was having from this medicine. Ekko then started having seizures in May,June and July. Stopped meds and he has had 3 more seizures since. I called the vet and she gave me anitdiarrhea medicine. Started in February and within a couple of weeks ears started twitching. I wish I read these side effects before my vet recommended Simparica Trio for my 12 week old Bichon. Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. He never ever used to do this. Nothing stopped the seizures and our Pickles passed away after just a few months of symptoms. RELATED: Signs Your Dog Might Be Having a Seizure. My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. Do not give extra or double doses. I will do anything to stop this from hurting or killing anyone else's baby. Vet office said make sure to give with food. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Called his vet and they gave no information. I will never use this stuff again and will tell anyone I see buying it or using it my story and yours too. Will not be using this treatment again!!! Im done with this drug! Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. 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