For this reason, it is important to buy milk thistle from reputable retailers. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. The name milk thistle is associated with the legend of Mother Mary. All rights reserved. Han YU, Guo D, Chen Y, et al. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. It is lauded for its anti-inflammatory properties and several health benefits. It also seems to have antioxidant and anti-inflammatory effects. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. What. Keep all medications and herbal products away from children and pets. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. However, more direct research is warranted in this regard. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. Its seed might protect liver cells from toxic chemicals and drugs. Duplication is encouraged. 3 are moderate, and 1 is minor. Side effects are always possible when taking supplements. 2018;9:1903. doi:10.3389/fimmu.2018.01903. Agency for Healthcare Research and Quality (US); 2000. It also looks at how to use milk thistle and whether there are any risks to consider. However, few of these claims are supported by solid evidence. People can purchase milk thistle supplements in health food stores or online. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. Substances in milk thistle may reduce blood sugar. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Some, but not all, milk thistle supplements are vegan. National Center for Complementary and Integrative Health. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). 1982;17:51721. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Milk thistle (PDQ) health professional version. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Milk thistle (PDQ) patient version. Of the total drug interactions, ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Milk thistle. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Taking too much milk thistle may increase the likelihood of side effects. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Milk thistle is sold as an oral capsule, tablet and liquid extract. How should we deal with preliminary information such as this? Milk Thistle; Silybum marianum; St. Mary's Thistle. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. StatPearls Publishing; 2022. Deng JW, Shon JH, Shin HJ, et al. You can buy milk thistle online in the supplement form. de Avelar CR, Pereira EM, de Farias Costa PR, et al. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Yes, you can drink alcohol while taking milk thistle. Phytother Res. Spiny stems branch at the top and reach heights of 5 to 10 feet. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. What is the daily upper limit for milk thistle? Studies show that silymarin may help ease inflammation and promote cell repair. Take your next dose at the regular time. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Milk thistle. Milk thistle might also decrease hormone levels in the body (5). To avoid complications, be sure to tell your healthcare provider about any supplements you take. For this reason, people who take diabetes medication may need to avoid milk thistle. Who should not take Milk Thistle Capsule? Toxicity is also possible if too much milk thistle is taken. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. These reactions may occur if you have an allergy to milk thistle. Over-indulging in this powerful herb may do you more harm than you know. Therefore, it may be best to avoid milk thistle during these life stages. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. Some people may be allergic to milk thistle. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. 2016;2016:5147468. doi:10.1155/2016/5147468. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. Gillessen A, Schmidt HH. jaundice. This is not a complete list of side effects and others may occur. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. You may report side effects to FDA at 1-800-FDA-1088. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. Check out our. It may not be safe for people with hormone-sensitive breast cancer. Adv Ther. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Can you drink alcohol while taking milk thistle? It may help treat diabetes, increase breast milk production, and improve liver functioning. There are 4 drugs known to interact with However, many of these potential benefits are not backed by science. It is now found throughout the world. You can learn more about how we ensure our content is accurate and current by reading our. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. All medications and herbal products away from children and pets an allergy to thistle! 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