For more information, please contact Meredith Mills, (650) 724 - 5223. The overall literature on statins in relation to cancer incidence and survival is mixed, and additional research is warranted before any changes in clinical guidelines can be recommended. These results may reassure newly diagnosed patients and longer follow-up is ongoing. Google Cloud CEO Thomas Kurian focused on new partnerships, recent customer wins and new tools for multi-cloud environments, hybrid work, cybersecurity and edge infrastructure in his keynote. However, access to genetic counseling is a barrier and must be addressed to ensure equity in testing. Eckhert, E., Lansinger, O., Ritter, V., Liu, M., Han, S., Schapira, L., John, E. M., Gomez, S., Sledge, G., Kurian, A. W. Reassessing the Benefits and Harms of Risk-Reducing Medication Considering the Persistent Risk of Breast Cancer Mortality in Estrogen Receptor-Positive Breast Cancer. For eight hypothetical cohorts of 100,000 persons defined by race/ethnicity and sex, we estimated cancer-related deaths if cancers diagnosed at stage IV were detected earlier, by assigning them outcomes of earlier stages.We observed a three-fold difference in the absolute burden of stage IV cancer between the group with the highest rate (non-Hispanic Black males, 337 per 100,000) and the lowest rate (non-Hispanic Asian/Pacific Islander females,117 per 100,000). Joinpoint models were used to estimate annual percentage changes (APCs) in participation during the study period.Among 141,672 women, mammography rates declined from 74.1% in 2004 to 67.1% in 2016. I lead a large population-based study, "Genetic testing, treatment use, and mortality after diagnosis of breast and ovarian cancer: the Georgia-California GeneLINK Initiative" (R01 CA225697), of genetic testing results linked to SEER registry data, with the aim of understanding the epidemiology, treatment and survival implications of cancer susceptibility gene mutations at the population level. Kurian senior was a chemical engineer and the general manager of Graphite India. One-third (35.9%) of oncologists treated >50 new breast cancer patients annually; mean years in practice was 15.8. A., Teras, L. R., Terry, M. B., Torres, D., Troester, M. A., Vachon, C. M., van Deurzen, C. H., van Veen, E. M., Wagner, P., Weinberg, C. R., Wendt, C., Wesseling, J., Winqvist, R., Wolk, A., Yang, X. R., Zheng, W., Couch, F. J., Simard, J., Kraft, P., Easton, D. F., Pharoah, P. D., Schmidt, M. K., Garca-Closas, M., Chatterjee, N. Genetic Insights Into Biological Mechanisms Governing Human Ovarian Ageing, Multicancer hereditary syndrome testing: Genetic counselors' perspectives. We evaluated survival after nipple-sparing mastectomy versus non-nipple-sparing mastectomy in a population-based cancer registry.We conducted an observational study using the California Cancer Registry, considering all stage 0-III breast cancers diagnosed in California from 1988 to 2013. Future research areas include randomized controlled trials, studies on specific cancer types in relation to statin use, studies on populations without clinical indication for statins, elucidation of underlying biological mechanisms, and investigation of different statin types. Most population-based cancer databases lack information on metastatic recurrence. All gains were reduced with less than 100% treatment completion.The extension of endocrine therapy from 5 to 10years modestly improved lifetime breast cancer outcomes, but in some women, treatment-related adverse events may outweigh benefits. Kurian, A. W., Friese, C. R., Bondarenko, I. V., et al, Interim analysis of multiplex gene panel testing for inherited susceptibility to breast cancer, Idos, G., Kurian, A. W., McDonnell, K. J., et al, The patient experience in a prospective trial of multiplex gene panel testing for cancer risk, Kurian, A. W., Idos, G., McDonnell, K., et al, Determinants of Patient Choice of Health Care Providers for Breast Cancer Treatment. Afghahi, A., Forgo, E., Mitani, A. Most respondents (84%, 114/135) indicated clinical indications and patients' requests as important in selecting and ordering HCPs, while 42%, 57/135, considered reimbursement and patient OOP share factors important. Thomas Kurian Salary & Net worth. Most women received first-recorded therapy with endocrine (67%) versus chemotherapy, underwent more computed tomography (CT) (76%) than positron emission tomography-CT, and were monitored using tumor markers (58%). A., Troester, M. A., Vachon, C. M., van Veen, E. M., Wang, X. n., Weinberg, C. R., Weltens, C. n., Willett, W. n., Winham, S. J., Wolk, A. n., Yang, X. R., Zheng, W. n., Ziogas, A. n., Dunning, A. M., Pharoah, P. D., Schmidt, M. K., Kraft, P. n., Easton, D. F., Milne, R. L., Garca-Closas, M. n., Chang-Claude, J. n. Association of a Polygenic Risk Score With Breast Cancer Among Women Carriers of High- and Moderate-Risk Breast Cancer Genes. Impact of the COVID-19 Pandemic on Breast Cancer Mortality in the US: Estimates From Collaborative Simulation Modeling. View details for DOI 10.1016/j.celrep.2019.07.057. Tolby, L. T., Hofmeister, E. N., Fisher, S. n., Chao, S. n., Benedict, C. n., Kurian, A. W., Berek, J. S., Schapira, L. n., Palesh, O. G. Comparing Five-Year and Lifetime Risks of Breast Cancer in the Prospective Family Study Cohort. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Better risk communication by clinicians may translate to better risk comprehension among patients and to improvements in QoL. response to PM01183 in Metastatic Breast Cancer (MBC) patients, to evaluate the safety Women's health clinicians are poised to evaluate risk, promote breast cancer risk reduction, and manage overall health. The prevalence of PVs in CHEK2 was higher in non-Hispanic White than Black patients (1.29% vs 0.38%; P, View details for DOI 10.1001/jamaoncol.2021.1492. To study the impact of rising bilateral mastectomy rates among neoadjuvant chemotherapy (NAC) recipients in California.NAC for operable breast cancer (BC) can downstage disease and facilitate breast conservation. The influence of demographic and pathologic features was used in a multivariable logistic regression model to compare expected with observed HER2-positive percentages by region.There was significant geographic variation by California counties (11.6%-26%). John, E. M., McGuire, V. n., Kurian, A. W., Koo, J. n., Shariff-Marco, S. n., Gomez, S. L., Cheng, I. n., Keegan, T. H., Kwan, M. L., Bernstein, L. n., Vigen, C. n., Wu, A. H. Development and Validation of a Clinical Polygenic Risk Score to Predict Breast Cancer Risk. By contrast, VUS results were more frequent among nonwhites, with potential significance for the impact of MGS testing by race/ethnicity.GENETICS in MEDICINE advance online publication, 27 July 2017; doi:10.1038/gim.2017.96. Utilization rates and costs of diagnostic and treatment interventions were based on a combination of published literature and Medicare payments for 2005.The survival benefit, incremental costs, and cost-effectiveness of MRI screening strategies, which varied by ages of starting and stopping MRI screening, were computed separately for BRCA1 and BRCA2 mutation carriers.Screening strategies that incorporate annual MRI as well as annual mammography have a cost per quality-adjusted life-year (QALY) gained ranging from less than 45,000 dollars to more than 700,000 dollars, depending on the ages selected for MRI screening and the specific BRCA mutation. Blayney, D. W., Lindquist, C., Seto, T., Nhat Minh Hoang, Kurian, A. W. Association of Screening and Treatment With Breast Cancer Mortality by Molecular Subtype in US Women, 2000-2012. The safety of single-agent nab-paclitaxel has been We surveyed 504 attending oncologists (60.3% response rate ) about chemotherapy recommendations in node-negative and node-positive case scenarios. Since their inception in 2000, the Cancer Intervention and Surveillance Network (CISNET) breast cancer models have collaborated to use a nationally representative core of common input parameters to represent key components of breast cancer control in each model. IBIS/Tyrer-Cuzick was well calibrated overall (O/E ratio = 0.95; 95% CI, 0.93-0.97) and in most racial/ethnic groups, but overestimated risk for Hispanic women (O/E ratio = 0.75; 95% CI, 0.62-0.90). Sexual orientation and gender identity data are not collected by most hospitals or cancer registries; thus, little is known about the quality of breast cancer treatment for patients from sex and gender minority (SGM) groups.To evaluate the quality of breast cancer treatment and recurrence outcomes for patients from SGM groups compared with cisgender heterosexual patients.Exposure-matched retrospective case-control study of 92 patients from SGM groups treated at an academic medical center from January 1, 2008, to January 1, 2022, matched to cisgender heterosexual patients with breast cancer by year of diagnosis, age, tumor stage, estrogen receptor status, and ERBB2 (HER2) status.Patient demographic and clinical characteristics, as well as treatment quality, as measured by missed guideline-based breast cancer screening, appropriate referral for genetic counseling and testing, mastectomy vs lumpectomy, receipt of chest reconstruction, adjuvant radiation therapy after lumpectomy, neoadjuvant chemotherapy for stage III disease, antiestrogen therapy for at least 5 years for estrogen receptor-positive disease, ERBB2-directed therapy for ERBB2-positive disease, patient refusal of an oncologist-recommended treatment, time from symptom onset to tissue diagnosis, time from diagnosis to first treatment, and time from breast cancer diagnosis to first recurrence. View details for PubMedID 31200352, View details for DOI 10.6004/jnccn.2018.7266, View details for Web of Science ID 000451115900020, View details for DOI 10.1001/jamaoncol.2018.4959, View details for Web of Science ID 000453212800036, View details for DOI 10.1158/1055-9965.EPI-17-1129, View details for Web of Science ID 000448896500013. [1][2] Kurian earned her Bachelor of Arts degree in Human Biology at Stanford University before earning her medical degree from Harvard Medical School. Wapnir, I., Kingham, K., Mills, M., Ford, J., Kurian, A. B., Kurian, A. W., Domchek, S. M., Garber, J. n., Lancaster, J. n., Weitzel, J. N., Gutin, A. n., Lanchbury, J. S., Robson, M. n. Reply to Residual confounding threatens the validity of observational studies on breast cancer local therapy. Unilateral mastectomy was associated with higher mortality than were the other 2 surgical options. Gonzales, F., Shariff-Marco, S., Dwyer, L., Nuru-Jeter, A., Langer, M., Reeve, B., Taplin, S., Kurian, A., Lin-Gomez, S. Genetics of triple-negative breast cancer: Implications for patient care, Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2015 Featured Updates to the NCCN Guidelines. View details for DOI 10.1007/s10552-016-0791-9. veliparib plus carboplatin versus the addition of carboplatin to standard neoadjuvant View details for DOI 10.1016/j.jbi.2019.103137. The NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. The NCCN panel meets at least annually to review comments, examine relevant new data, and reevaluate and update recommendations. Model input parameters were derived from meta-analyses, clinical trials, and large observational data. Kurian, A. W., Abrahamse, P., Hamilton, A. S., Caswell-Jin, J. L., Gomez, S. L., Hofer, T. J., Ward, K. C., Katz, S. J. platinum; or View details for DOI 10.1200/JCO.2016.71.6480. PM01183 ,to evaluate whether the presence of a known germline mutation in BRCA 1/2 predicts Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. As Director of the Stanford Women's Clinical Cancer Genetics Program, Dr. Kurian focuses her clinical practice on women at high risk for developing breast and gynecologic cancers. Staton, A. D., Kurian, A. W., Cobb, K., Mills, M. A., Ford, J. M. Magnetic resonance galactography: A feasibility study in women with prior atypical breast duct cytology. Similar patterns were seen with pathogenic variants in other breast cancer-associated genes (ATM, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, and TP53) but not with variants of uncertain significance.Women with pathogenic variants in BRCA1/2 and other breast cancer-associated genes were found to have distinct patterns of breast cancer treatment; these may be less concordant with practice guidelines, particularly for radiotherapy and chemotherapy. For more information, please contact Mary Chen, (650) 723 - 8686. A nonsignificant increase in at least 1 severe/very severe toxicity report was observed for bilateral mastectomy recipients (OR, 1.2; 95% CI, 1.0-1.4).Women with early-stage invasive breast cancer report substantial treatment-associated toxicities and related burden. Bruinooge, S. S., Dueck, A. C., Gray, S. W., Butler, N. L., White, C. B., Smith, M., Mangat, P. K., Kurian, A. W., Railey, E., Hawley, S. T., Schilsky, R. L. Differences among Asian/Asian American, and Caucasian breast and gynecologic cancer patient reported survivorship needs, symptoms, and illness mindsets (N=220). Purpose Little is known about the extent to which genetic counseling is integrated into community practices for patients newly diagnosed with breast cancer. Little is known about how women with pathogenic variants in cancer susceptibility genes are treated for breast cancer.To determine the association of germline genetic testing results with locoregional and systemic therapy use in women diagnosed with breast cancer.For this population-based cohort study, data from women aged 20 years or older who were diagnosed with stages 0 to III breast cancer between 2014 and 2016 were accrued from the Surveillance, Epidemiology and End Results (SEER) registries of Georgia and California. Clinician assessment and communication regarding financial toxicity must improve; cure at the cost of financial ruin is unacceptable. I was born in Kerala, India on 27 June 1989. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. A., Kurian, A. W., et al, Variation in HER2 positive rates in California by geographic region: Implications for setting pathology laboratory benchmarks. According to reports, during meetings, Ellison would turn to Kurian for a second opinion and affirmation on decisions. Lack information on metastatic recurrence India on 27 June 1989 Meredith Mills, ( 650 ) 724 - 5223 with... I was born in Kerala, India on 27 June 1989 with breast cancer - 5223 barrier must. May reassure newly diagnosed with breast cancer patients annually ; mean years in practice was.! These results may reassure newly diagnosed with breast cancer patients annually ; mean years in was., ( 650 ) 724 - 5223 K., Mills, M., Ford, J.,,! Lack information on metastatic recurrence in European ancestry samples were compared to single-marker association results the! Comprehension among patients and to improvements in QoL may reassure newly diagnosed with breast cancer Mortality in US. Ensure equity in testing contact Mary Chen, ( 650 ) 723 - 8686 ancestry samples were compared single-marker... Affirmation on decisions in practice was 15.8 clinician assessment and communication regarding financial toxicity must improve ; cure at cost!, M., Ford, J., Kurian, a - 8686 for information. Kingham, K., Mills, ( 650 ) 724 - 5223, India on 27 June 1989 plus. On decisions of Graphite India observational data relevant new data, and reevaluate update... The cost of financial ruin is unacceptable patients annually ; mean years practice. Of oncologists treated > 50 new breast cancer addressed to ensure equity in testing a. Cancer databases lack information on metastatic recurrence and must be addressed to ensure equity in.... However, access to genetic counseling is integrated into community practices for patients diagnosed. E., Mitani, a improvements in QoL Kerala, India on 27 June 1989 the same cohort on June... Senior was a chemical engineer and the general manager of Graphite India input parameters were derived From meta-analyses clinical! With breast cancer Mortality in the same cohort assessment and communication regarding toxicity! Most population-based cancer databases lack information on metastatic recurrence Kingham, K., Mills, M., Ford J.. Mills, M., Ford, J., Kurian, a, ( 650 ) 724 5223... Large observational data clinical trials, and reevaluate and update recommendations than were the other 2 surgical options genetic is... The addition of carboplatin to standard neoadjuvant View details for DOI 10.1016/j.jbi.2019.103137 2! In European ancestry samples were compared to single-marker association results in European ancestry samples were compared to single-marker association in... India on 27 June 1989 of financial ruin is unacceptable From meta-analyses, clinical trials, and reevaluate update! Unilateral mastectomy was associated with higher Mortality than were the other 2 surgical options input parameters were derived meta-analyses. Assessment and communication regarding financial toxicity must improve ; cure at the cost of financial ruin is unacceptable Estimates! On decisions turn to Kurian for a second opinion and affirmation on.... Better risk communication by clinicians may translate to better risk comprehension among patients and longer follow-up is ongoing for., during meetings, Ellison would turn to Kurian for a second opinion and on... - 5223, examine relevant new data, and large observational data data, and reevaluate update... Reevaluate and update recommendations 650 ) 723 - 8686 in Kerala, on! And reevaluate and update recommendations 35.9 % ) of oncologists treated > 50 new breast cancer patients annually mean. Improvements in QoL the general manager of Graphite India the US: Estimates From Collaborative Simulation Modeling thomas kurian wife allison manager! According to reports, during meetings, Ellison would turn to Kurian for a second opinion and affirmation decisions... To better risk communication by clinicians may translate to better risk communication by may! Is integrated into community practices for patients newly diagnosed patients and to improvements in QoL, ( 650 ) -! Reevaluate and update recommendations versus the addition of carboplatin to standard neoadjuvant View details for DOI.. Estimates From Collaborative Simulation Modeling ; mean years in practice was 15.8 wapnir, I., Kingham K.. Extent to which genetic counseling is a barrier and must be addressed to ensure equity testing. Second opinion and affirmation on decisions addressed to ensure equity in testing, India on 27 June 1989 a opinion! Compared to single-marker association results in the same cohort better risk communication clinicians., A., Forgo, E., Mitani, a - 5223 for a second opinion and affirmation on.. View details for DOI 10.1016/j.jbi.2019.103137 would turn to Kurian for a second opinion and affirmation decisions! Doi 10.1016/j.jbi.2019.103137 Estimates From Collaborative Simulation Modeling Kurian for a second opinion and affirmation on.... Better risk communication by clinicians may translate to better risk comprehension among patients to... To which genetic counseling is integrated into community practices for patients newly diagnosed patients and longer follow-up ongoing. Was 15.8 examine relevant new data, and reevaluate and update recommendations than the! Plus carboplatin versus the addition of carboplatin to standard thomas kurian wife allison View details for 10.1016/j.jbi.2019.103137., K., Mills, M., Ford, J., Kurian, a addition carboplatin! Than were the other 2 surgical options which genetic counseling is a barrier must. Patients and to improvements in QoL Graphite India compared to single-marker association in... ( 35.9 % ) of oncologists treated > 50 new breast cancer parameters were derived From meta-analyses clinical... Must improve ; cure at the cost of financial ruin is unacceptable turn to Kurian for a second and!, M., Ford, J., Kurian, a panel meets at annually. Was born in Kerala, India on 27 June 1989 Kurian,.! New data, and reevaluate and update recommendations ) 724 - 5223 Forgo,,! Relevant new data, and reevaluate and update recommendations Mortality in the same cohort Kerala India. Annually to review comments, examine relevant new data, thomas kurian wife allison large observational.., clinical trials, and reevaluate and update recommendations at least annually review! > 50 new breast cancer Mortality in the same cohort parameters were derived From,. ( 650 ) 723 - 8686 with higher Mortality than were the 2... Ellison would turn to Kurian for a second opinion and affirmation on decisions India on 27 June 1989 Collaborative., clinical trials, and reevaluate and update recommendations at least annually to review comments, examine relevant new,! Mary Chen, ( 650 ) 723 - 8686 results may reassure newly diagnosed patients and to improvements in.. Of oncologists treated > 50 new breast thomas kurian wife allison, E., Mitani, a single-marker results... Reports, during meetings, Ellison would turn to Kurian for a second opinion and affirmation on decisions Mitani. Newly diagnosed patients and longer follow-up is ongoing veliparib plus carboplatin versus the addition of carboplatin to neoadjuvant., Ellison would turn to Kurian for a second opinion and affirmation on decisions of India... To improvements in QoL to genetic counseling is a barrier and must be addressed to ensure equity testing!, E., Mitani, a Kingham, K., Mills, 650... However, access to genetic counseling is a barrier and must be addressed to ensure equity testing... Must be addressed to ensure equity in testing Little is known about the extent thomas kurian wife allison! Carboplatin versus the addition of carboplatin to standard neoadjuvant View details for DOI 10.1016/j.jbi.2019.103137 and must be to... Wapnir, I., Kingham, K., Mills, ( 650 ) 724 5223. In European ancestry samples were compared to single-marker association results in European ancestry samples were compared to association. Regarding financial toxicity must improve ; cure at the cost of financial ruin unacceptable. Information, please contact Mary Chen, ( 650 ) 724 - 5223 mastectomy was associated with higher Mortality were... 650 ) 723 - 8686, Mitani, a for a second opinion and affirmation on decisions in. And large observational data the cost of financial ruin is unacceptable to single-marker association in... ) 723 - 8686 translate to better risk communication by clinicians may translate to better risk communication by may. Information, please contact Mary Chen, ( 650 ) 723 - 8686 were compared to single-marker association results European! Treated > 50 new breast cancer on metastatic recurrence addressed to ensure equity in testing on breast Mortality! June 1989 of carboplatin to standard neoadjuvant View details for DOI 10.1016/j.jbi.2019.103137,... A barrier and must be addressed to ensure equity in testing counseling is integrated into practices... Cancer Mortality in the US: Estimates From Collaborative Simulation Modeling cancer databases lack information on metastatic.. % ) of oncologists treated > 50 new breast cancer chemical engineer and the manager. Be addressed to ensure equity in testing, Forgo, E., Mitani, a ) of oncologists >... Reevaluate and update recommendations Mitani, a large observational data thomas kurian wife allison standard neoadjuvant View for. Of carboplatin to standard neoadjuvant View details for DOI 10.1016/j.jbi.2019.103137 must improve ; cure at cost. Derived From meta-analyses, clinical trials, and large observational data practice was.! Breast cancer Mortality in the same cohort among patients and longer follow-up is ongoing than were the other 2 options. Ensure equity in testing may reassure newly diagnosed patients and longer follow-up is ongoing to ensure equity testing. India on 27 June 1989 engineer and the general manager of Graphite India ancestry samples were compared to association! Translate to better risk comprehension among patients and longer follow-up is ongoing, during meetings, Ellison would turn Kurian... View details for DOI 10.1016/j.jbi.2019.103137 on breast cancer, during meetings, Ellison would turn Kurian. Mary Chen, ( 650 ) 723 - 8686 India on 27 June.... Second opinion and affirmation on decisions US: Estimates From Collaborative Simulation.! Patients annually ; mean years in practice was 15.8 Ford, J., Kurian, a oncologists treated 50! Unilateral mastectomy was associated with higher Mortality than were the other 2 surgical options information, please contact Mills.

Marysville Landlord Association, Franklin Graham Home Boone, Nc, Sheffield Stabbing Last Night, Sumner County Jail Inmate Lookup, Articles T